Genetic Analysis of Prostatic Atypical Adenomatous Hyperplasia (Adenosis)

Helen Donis-Keller, Franklin W. Olin College of Engineering
Jennifer A. Doll
Xiaopei Zhu
Jaime Furman
Zahid Kaleem
Carlos Torres
Peter A. Humphrey

© 1999 American Society for Investigative Pathology. This article was published in American Journal of Pathology, vol. 155, no. 3, p. 967-971.

Abstract

Atypical adenomatous hyperplasia (AAH) of the prostate,a small glandular proliferation, is a putative precursorlesion to prostate cancer, in particular to thesubset of well-differentiated carcinomas that arise inthe transition zone, the same region where AAH lesionsmost often occur. Several morphological characteristicsof AAH suggest a relationship to cancer;however, no definitive evidence has been reported.In this study, we analyzed DNA from 25 microdissectedAAH lesions for allelic imbalance as comparedto matched normal DNA, using one marker each fromchromosome arms 1q, 6q, 7q, 10q, 13q, 16q, 17p,17q, and 18q, and 19 markers from chromosome 8p.We observed 12% allelic imbalance, with loss onlywithin chromosome 8p11–12. These results suggestthat genetic alterations in transition zone AAH lesionsmay be infrequent. This genotypic profile of AAH willallow for comparisons with well-differentiated carcinomasin the transition zone of the prostate. (Am JPathol 1999, 155:967–971)